Reprogramming tumor-associated macrophages as a unique approach to target tumor immunotherapy

SU Khan, MU Khan, M Azhar Ud Din, IM Khan… - Frontiers in …, 2023 - frontiersin.org
In the last ten years, it has become increasingly clear that tumor-infiltrating myeloid cells
drive not just carcinogenesis via cancer-related inflammatory processes, but also tumor …

The CAR macrophage cells, a novel generation of chimeric antigen-based approach against solid tumors

K Hadiloo, S Taremi, M Heidari, A Esmaeilzadeh - Biomarker Research, 2023 - Springer
Today, adoptive cell therapy has many successes in cancer therapy, and this subject is
brilliant in using chimeric antigen receptor T cells. The CAR T cell therapy, with its FDA …

[HTML][HTML] Inulin alleviates inflammation of alcoholic liver disease via SCFAs-inducing suppression of M1 and facilitation of M2 macrophages in mice

Z Wang, X Zhang, L Zhu, X Yang, F He, T Wang… - International …, 2020 - Elsevier
Background Alcoholic liver disease (ALD) presents one of the leading causes of cirrhosis
worldwide. We have demonstrated that inulin alleviates ALD in mice. However, the exact …

m6A-immune-related lncRNA prognostic signature for predicting immune landscape and prognosis of bladder cancer

ZH Feng, YP Liang, JJ Cen, HH Yao, HS Lin… - Journal of Translational …, 2022 - Springer
Abstract Background N6-methyladenosine (m6A) related long noncoding RNAs (lncRNAs)
may have prognostic value in bladder cancer for their key role in tumorigenesis and innate …

Multifunctional gold clusterzymes with distinct glucose depletion and macrophage reprogramming capability towards regulating the regeneration cascade

T Wang, Z Xu, M Wen, N Li, L Zhang, Y Xue… - Chemical Engineering …, 2024 - Elsevier
Treating diabetic wounds remains a significant clinic challenge nowadays, where one of the
major hurdles is hyperglycemia. Particularly, hyperglycemia sets off a cascade of changes in …

[PDF][PDF] The inflammatory profile of the tumor microenvironment, orchestrated by cyclooxygenase-2, promotes epithelial-mesenchymal transition

F Gómez-Valenzuela, E Escobar… - Frontiers in …, 2021 - frontiersin.org
The tumor microenvironment (TME) corresponds to a complex and dynamic interconnection
between the extracellular matrix and malignant cells and their surrounding stroma …

Nanomaterials-Involved Tumor-Associated Macrophages' Reprogramming for Antitumor Therapy

SL Li, HY Hou, X Chu, YY Zhu, YJ Zhang, MD Duan… - ACS …, 2024 - ACS Publications
Tumor-associated macrophages (TAMs) play pivotal roles in tumor development. As primary
contents of tumor environment (TME), TAMs secrete inflammation-related substances to …

Multiomics analysis reveals cuproptosis-related signature for evaluating prognosis and immunotherapy efficacy in colorectal cancer

R He, H Zhang, H Zhao, X Yin, J Lu, C Gu, J Gao, Q Xu - Cancers, 2023 - mdpi.com
Simple Summary Cuproptosis is a newly discovered copper-dependent cell death. We
aimed to explore the functions of cuproptosis in the tumor microenvironment and construct a …

Elevated levels of MMP12 sourced from macrophages are associated with poor prognosis in urothelial bladder cancer

IK Kerzeli, A Kostakis, P Türker, PU Malmström… - BMC cancer, 2023 - Springer
Background Urothelial bladder cancer is most frequently diagnosed at the non-muscle-
invasive stage (NMIBC). However, recurrences and interventions for intermediate and high …

Pretreatment tumour immune microenvironment predicts clinical response and prognosis of muscle-invasive bladder cancer in the neoadjuvant chemotherapy setting

D Ikarashi, S Kitano, T Tsuyukubo… - British Journal of …, 2022 - nature.com
Background We examined the relationship between the tumour microenvironment and the
clinical efficacy of neoadjuvant chemotherapy in patients with cT2-4aN0M0 bladder cancer …