The general mechanisms that control the cell cycle in mammalian cells have been studied in
depth and several proteins that are involved in the tight regulation of cell cycle progression …

SUMMARY Simian virus 40 (SV40) is a small DNA tumor virus that has been extensively
characterized due to its relatively simple genetic organization and the ease with which its …

Small DNA tumor viruses have evolved different mechanisms to abrogate the function of the
retinoblastoma tumor suppressor (pRb). Studies of these viruses have been invaluable in …

Cysteine-rich protein 61 (Cyr61) is a member of a family of growth factor-inducible
immediate-early genes. It regulates cell adhesion, migration, proliferation, and differentiation …

Rb family proteins (pRb/p105, Rb2/p130 and p107) play a key role in cell cycle control and
are worthily involved in transcription repression and tumor suppression. The mechanisms of …

Abstract α-Synuclein (α-syn), a 14 kDa pre-synaptic protein, is widely involved in the
Parkinson's disease (PD) pathogenesis. Recent studies have shown that the nuclear …

The retinoblastoma (Rb) family consists of the tumor suppressor pRb/p105 and related
proteins p107 and pRb2/p130. Recent immunohistochemical studies of the retinoblastoma …

α-Synuclein is a presynaptic protein that accumulates abnormally in Lewy bodies of
Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Its physiological function …

The amino termini of polyomavirus T antigens contain LXCXE and J domains, which are
necessary for binding and inactivating the retinoblastoma family of tumor suppressors. Both …

An understanding of the mechanisms that uncover the dynamic changes in the distribution of
the chromatin modifying enzymes and regulatory proteins on their target loci could provide …