Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was
first documented. However, its continued use is challenged by its poor tolerability, poor …

Approximately 40% of the world population live in areas with the risk of malaria. Each year,
300–500 million people suffer from acute malaria, and 0.5–2.5 million die from the disease …

Several classes of antibiotics exert antimalarial activity. The mechanisms of action of
antibiotics against malaria parasites have been unclear, and prior studies have led to …

Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

Antimicrobial chemotherapy has played a vital role in the treatment of human infectious
diseases since the discovery of penicillin in the 1920s. Hundreds of antimicrobial agents …

Multidrug resistance has rendered monotherapy for malaria useless in most parts of the
world, and has also compromised the usefulness of many of the available combination …

The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …

New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …

Lincomycin and clindamycin are lincosamide antibiotics used in clinical practice. Both
antibiotics are bacteriostatic and inhibit protein synthesis in sensitive bacteria. They may …

Plasmodium falciparum and Plasmodium vivax, the two protozoan parasite species that
cause the majority of cases of human malaria, have developed resistance to nearly all …