Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. Sepsis can induce acute kidney injury and multiple organ failures …

Immunocompromised patients account for an increasing proportion of the typical intensive
care unit (ICU) case-mix. Because of the increased availability of new drugs for cancer and …

Background A COVID-19 outbreak started in Wuhan, China, last December and now has
become a global pandemic. The clinical information in caring of critically ill patients with …

Emerged evidence has indicated that immunosuppression is involved in the occurrence and
development of sepsis. To provide clinical practice recommendations on the immune …

Background Neutropenia increases the risk of infection, but it is unknown if this also applies
to lymphopenia. We therefore tested the hypotheses that lymphopenia is associated with …

Purpose Cellular immune dysfunctions, which are common in intensive care patients, predict
a number of significant complications. In order to effectively target treatments, clinically …

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. Sestrin2 (SESN2), a highly evolutionarily conserved protein, is …

We report a longitudinal analysis of the immune response associated with a fatal case of
COVID-19 in Europe. This patient exhibited a rapid evolution towards multiorgan failure …

Rationale Predicting long-term outcomes in sepsis survivors remains a difficult task.
Persistent inflammation post-sepsis is associated with increased risk for rehospitalization …

Sepsis is the uncontrolled reaction of the body to infection-induced inflammation, which
results in life-threatening multiple-organ dysfunction (MODS). Although the research on …