Tranexamic acid (TXA) is a widely used antifibrinolytic agent that has been used since the
1960's to reduce blood loss in various conditions. TXA is a lysine analogue that competes …

Severe hemostatic disturbances and impaired fibrinolysis occur in sepsis. In the most
serious cases, the dysregulation of fibrinolysis contributes to septic shock, disseminated …

In the last decades, it has become evident that endothelial cells (ECs) in the
microvasculature play an important role in the pathophysiology of sepsis-associated multiple …

Tissue engineering technology has advanced rapidly in recent years, offering opportunities
to construct biologically active tissues or organ substitutes to repair or even enhance the …

Macrophages are important effectors of inflammation resolution that contribute to the
elimination of pathogens and apoptotic cells and restoration of homeostasis. Pre-clinical …

Abstract The Plasminogen/Plasmin (Plg/Pla) system, best known for its classical role in
thrombolysis, has been recently highlighted as a regulator of other biological processes in …

Background & aims Sepsis, a globally prevalent and highly lethal condition, remains a
critical medical challenge. This investigation aims to assess the relevance of FGF1 as a …

Surgical sutures are necessary for the rotator cuff (RC) repair to reconnect the torn and
degenerating cuff tendon to its footprint. Early‐stage immunomodulation, angiogenesis, and …

Improving our understanding on the clinical role of plasmin-mediated von Willebrand factor
degradation Page 1 MOH 310504 CURRENT OPINION Improving our understanding on the …

Pseudomonas aeruginosa is a frequent cause of antimicrobial‐resistant hospital‐acquired
pneumonia, especially in critically ill patients. Inflammation triggered by P. aeruginosa …