Triazole derivatives and their antiplasmodial and antimalarial activities

XM Chu, C Wang, WL Wang, LL Liang, W Liu… - European journal of …, 2019 - Elsevier
Malaria, caused by protozoan parasites of the genus Plasmodium especially by the most
prevalent parasite Plasmodium falciparum, represents one of the most devastating and …

Chalcone hybrids as privileged scaffolds in antimalarial drug discovery: A key review

HL Qin, ZW Zhang, R Lekkala, H Alsulami… - European journal of …, 2020 - Elsevier
Malaria remains a serious worldwide health danger and massive economic trouble to
disease-endemic nations. Presently, 250 million of malarial cases are expected worldwide …

Green synthesis and anticancer potential of chalcone linked-1, 2, 3-triazoles

P Yadav, K Lal, A Kumar, SK Guru, S Jaglan… - European journal of …, 2017 - Elsevier
A series of chalcone linked-1, 2, 3-triazoles was synthesized via cellulose supported copper
nanoparticle catalyzed click reaction in water. The structures of all the compounds were …

Ferrocene-appended pharmacophores: An exciting approach for modulating the biological potential of organic scaffolds

A Singh, I Lumb, V Mehra, V Kumar - Dalton transactions, 2019 - pubs.rsc.org
Two exemplary contributions of organometallics in medicinal chemistry, ferroquine and
ferrocifen, which exhibit excellent anti-plasmodial and anti-cancer activities, respectively …

Combination therapy strategies for the treatment of malaria

S Alven, B Aderibigbe - Molecules, 2019 - mdpi.com
Malaria is a vector-and blood-borne infection that is responsible for a large number of
deaths around the world. Most of the currently used antimalarial therapeutics suffer from …

Current scenario of ferrocene-containing hybrids for antimalarial activity

J Xiao, Z Sun, F Kong, F Gao - European Journal of Medicinal Chemistry, 2020 - Elsevier
Hybrid molecules have the potential to enhance the efficacy against both drug-sensitive and
drug-resistant organisms, and Ferroquine, a ferrocene hybrid, has demonstrated great …

[HTML][HTML] Recent advances in chalcone-triazole hybrids as potential pharmacological agents

A Bhukal, V Kumar, L Kumar, K Lal - Results in Chemistry, 2023 - Elsevier
Molecular hybridization is one of the recent strategies to synthesize a novel hybrid
compound by combining two or more pharmacophoric units. Being a linkage process, it …

1H-1, 2, 3-triazole tethered isatin-ferrocene conjugates: Synthesis and in vitro antimalarial evaluation

K Kumar, B Pradines, M Madamet, R Amalvict… - European journal of …, 2014 - Elsevier
Abstract 1H-1, 2, 3-triazole tethered isatin-ferrocene conjugates were synthesized and
evaluated for their antiplasmodial activities against chloroquine-susceptible (3D7) and …

Roles of virtual screening and molecular dynamics simulations in discovering and understanding antimalarial drugs

SS Duay, RCY Yap, AL Gaitano III, JAA Santos… - International Journal of …, 2023 - mdpi.com
Malaria continues to be a global health threat, with approximately 247 million cases
worldwide. Despite therapeutic interventions being available, patient compliance is a …

A strategic approach to the synthesis of ferrocene appended chalcone linked triazole allied organosilatranes: Antibacterial, antifungal, antiparasitic and antioxidant …

G Singh, A Arora, P Kalra, IK Maurya, CE Ruizc… - Bioorganic & Medicinal …, 2019 - Elsevier
A series of ferrocene appended chalcone allied triazole coupled organosilatranes (FCTSa 7–
FCTSa 12) were synthesised with the aim of amalgamating the pharmacological action of …