Serial femtosecond crystallography
TRM Barends, B Stauch, V Cherezov… - Nature reviews Methods …, 2022 - nature.com
With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial
crystallography techniques for macromolecular structure determination have emerged …
crystallography techniques for macromolecular structure determination have emerged …
Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons
Historically, room-temperature structure determination was succeeded by cryo-
crystallography to mitigate radiation damage. Here, we demonstrate that serial millisecond …
crystallography to mitigate radiation damage. Here, we demonstrate that serial millisecond …
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory
cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms …
cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms …
[HTML][HTML] XFELs for structure and dynamics in biology
JCH Spence - IUCrJ, 2017 - scripts.iucr.org
The development and application of the free-electron X-ray laser (XFEL) to structure and
dynamics in biology since its inception in 2009 are reviewed. The research opportunities …
dynamics in biology since its inception in 2009 are reviewed. The research opportunities …
[PDF][PDF] Serial millisecond crystallography of membrane and soluble protein microcrystals using synchrotron radiation
JM Martin-Garcia, CE Conrad, G Nelson, N Stander… - IUCrJ, 2017 - journals.iucr.org
Crystal structure determination of biological macromolecules using the novel technique of
serial femtosecond crystallography (SFX) is severely limited by the scarcity of X-ray free …
serial femtosecond crystallography (SFX) is severely limited by the scarcity of X-ray free …
A bright future for serial femtosecond crystallography with XFELs
X-ray free electron lasers (XFELs) have the potential to revolutionize macromolecular
structural biology due to the unique combination of spatial coherence, extreme peak …
structural biology due to the unique combination of spatial coherence, extreme peak …
Materials characterization by synchrotron x-ray microprobes and nanoprobes
In recent years synchrotron x-ray microprobes and nanoprobes have emerged as key
characterization tools with a remarkable impact for different scientific fields including solid …
characterization tools with a remarkable impact for different scientific fields including solid …
Human Adenosine A2A Receptor: Molecular Mechanism of Ligand Binding and Activation
B Carpenter, G Lebon - Frontiers in pharmacology, 2017 - frontiersin.org
Adenosine receptors (ARs) comprise the P1 class of purinergic receptors and belong to the
largest family of integral membrane proteins in the human genome, the G protein-coupled …
largest family of integral membrane proteins in the human genome, the G protein-coupled …
Recent advances in structure-based drug design targeting class AG protein-coupled receptors utilizing crystal structures and computational simulations
G protein-coupled receptors (GPCRs) represent the largest and most physiologically
important integral membrane protein family, and these receptors respond to a wide variety of …
important integral membrane protein family, and these receptors respond to a wide variety of …
[PDF][PDF] Toward G protein-coupled receptor structure-based drug design using X-ray lasers
Rational structure-based drug design (SBDD) relies on the availability of a large number of
co-crystal structures to map the ligand-binding pocket of the target protein and use this …
co-crystal structures to map the ligand-binding pocket of the target protein and use this …