Multiphysics and multiscale modelling, data–model fusion and integration of organ physiology in the clinic: ventricular cardiac mechanics

R Chabiniok, VY Wang… - Interface …, 2016 - royalsocietypublishing.org
With heart and cardiovascular diseases continually challenging healthcare systems
worldwide, translating basic research on cardiac (patho) physiology into clinical care is …

Heart blood flow simulation: a perspective review

SN Doost, D Ghista, B Su, L Zhong… - Biomedical engineering …, 2016 - Springer
Cardiovascular disease (CVD), the leading cause of death today, incorporates a wide range
of cardiovascular system malfunctions that affect heart functionality. It is believed that the …

A deep-learning approach for direct whole-heart mesh reconstruction

F Kong, N Wilson, S Shadden - Medical image analysis, 2021 - Elsevier
Automated construction of surface geometries of cardiac structures from volumetric medical
images is important for a number of clinical applications. While deep-learning-based …

Application of patient-specific computational fluid dynamics in coronary and intra-cardiac flow simulations: Challenges and opportunities

L Zhong, JM Zhang, B Su, RS Tan, JC Allen… - Frontiers in …, 2018 - frontiersin.org
The emergence of new cardiac diagnostics and therapeutics of the heart has given rise to
the challenging field of virtual design and testing of technologies in a patient-specific …

Personalized intervention cardiology with transcatheter aortic valve replacement made possible with a non-invasive monitoring and diagnostic framework

S Khodaei, A Henstock, R Sadeghi, S Sellers… - Scientific reports, 2021 - nature.com
One of the most common acute and chronic cardiovascular disease conditions is aortic
stenosis, a disease in which the aortic valve is damaged and can no longer function …

Image-based simulations show important flow fluctuations in a normal left ventricle: what could be the implications?

C Chnafa, S Mendez, F Nicoud - Annals of biomedical engineering, 2016 - Springer
Intra-cardiac flow has been explored for decades but there is still no consensus on whether
or not healthy left ventricles (LV) may harbour turbulent-like flow despite its potential …

Numerical simulation of patient-specific left ventricular model with both mitral and aortic valves by FSI approach

B Su, L Zhong, XK Wang, JM Zhang, R San Tan… - Computer methods and …, 2014 - Elsevier
Intraventricular flow is important in understanding left ventricular function; however, relevant
numerical simulations are limited, especially when heart valve function is taken into account …

Review of numerical methods for simulation of mechanical heart valves and the potential for blood clotting

MS Zakaria, F Ismail, M Tamagawa, AFA Aziz… - Medical & biological …, 2017 - Springer
Even though the mechanical heart valve (MHV) has been used routinely in clinical practice
for over 60 years, the occurrence of serious complications such as blood clotting remains to …

Towards a non-invasive computational diagnostic framework for personalized cardiology of transcatheter aortic valve replacement in interactions with complex …

S Khodaei, R Sadeghi, P Blanke, J Leipsic… - International Journal of …, 2021 - Elsevier
Aortic stenosis is an acute and chronic cardiovascular disease that often coexists with other
complex valvular, ventricular and vascular diseases (C3VD). Transcatheter aortic valve …

Automating model generation for image-based cardiac flow simulation

F Kong, SC Shadden - Journal of biomechanical …, 2020 - asmedigitalcollection.asme.org
Computational fluid dynamics (CFD) modeling of left ventricle (LV) flow combined with
patient medical imaging data has shown great potential in obtaining patient-specific …