Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

The autophagic pathway involves the encapsulation of substrates in double-membraned
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …

Chaperone-mediated autophagy (CMA) was the first studied process that indicated that
degradation of intracellular components by the lysosome can be selective—a concept that is …

The nanomaterial–protein “corona” is a dynamic entity providing a synthetic–natural
interface mediating cellular uptake and subcellular distribution of nanomaterials in biological …

In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …

Inhibiting cell survival and inducing cell death are the main approaches of tumor therapy.
Autophagy plays an important role on intracellular metabolic homeostasis by eliminating …

This review focuses on chaperone-mediated autophagy (CMA), one of the proteolytic
systems that contributes to degradation of intracellular proteins in lysosomes. CMA substrate …

Autophagy refers to a ubiquitous set of catabolic pathways required to achieve proper
cellular homeostasis. Aberrant autophagy has been implicated in a multitude of diseases …

ABSTRACT LAMP2 (lysosomal associated membrane protein 2) is one of the major protein
components of the lysosomal membrane. There currently exist three LAMP2 isoforms …

Doxorubicin (DOX), also known as adriamycin, is a DNA topoisomerase II inhibitor and
belongs to the family of anthracycline anticancer drugs. DOX is used for the treatment of a …