Autophagy in major human diseases
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
[HTML][HTML] Complex interplay between autophagy and oxidative stress in the development of pulmonary disease
W Ornatowski, Q Lu, M Yegambaram, AE Garcia… - Redox biology, 2020 - Elsevier
The autophagic pathway involves the encapsulation of substrates in double-membraned
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …
The coming of age of chaperone-mediated autophagy
Chaperone-mediated autophagy (CMA) was the first studied process that indicated that
degradation of intracellular components by the lysosome can be selective—a concept that is …
degradation of intracellular components by the lysosome can be selective—a concept that is …
Dynamic intracellular exchange of nanomaterials' protein corona perturbs proteostasis and remodels cell metabolism
The nanomaterial–protein “corona” is a dynamic entity providing a synthetic–natural
interface mediating cellular uptake and subcellular distribution of nanomaterials in biological …
interface mediating cellular uptake and subcellular distribution of nanomaterials in biological …
Targeting lysosomes in human disease: from basic research to clinical applications
M Cao, X Luo, K Wu, X He - Signal transduction and targeted therapy, 2021 - nature.com
In recent years, accumulating evidence has elucidated the role of lysosomes in dynamically
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …
regulating cellular and organismal homeostasis. Lysosomal changes and dysfunction have …
Targeting autophagy to overcome drug resistance: further developments
H Chang, Z Zou - Journal of hematology & oncology, 2020 - Springer
Inhibiting cell survival and inducing cell death are the main approaches of tumor therapy.
Autophagy plays an important role on intracellular metabolic homeostasis by eliminating …
Autophagy plays an important role on intracellular metabolic homeostasis by eliminating …
Chaperone-mediated autophagy: roles in disease and aging
AM Cuervo, E Wong - Cell research, 2014 - nature.com
This review focuses on chaperone-mediated autophagy (CMA), one of the proteolytic
systems that contributes to degradation of intracellular proteins in lysosomes. CMA substrate …
systems that contributes to degradation of intracellular proteins in lysosomes. CMA substrate …
[HTML][HTML] A perspective on the role of autophagy in cancer
Autophagy refers to a ubiquitous set of catabolic pathways required to achieve proper
cellular homeostasis. Aberrant autophagy has been implicated in a multitude of diseases …
cellular homeostasis. Aberrant autophagy has been implicated in a multitude of diseases …
LAMP2A, LAMP2B and LAMP2C: Similar structures, divergent roles
L Qiao, J Hu, X Qiu, C Wang, J Peng, C Zhang… - Autophagy, 2023 - Taylor & Francis
ABSTRACT LAMP2 (lysosomal associated membrane protein 2) is one of the major protein
components of the lysosomal membrane. There currently exist three LAMP2 isoforms …
components of the lysosomal membrane. There currently exist three LAMP2 isoforms …
Autophagy and doxorubicin resistance in cancer
C Chen, L Lu, S Yan, H Yi, H Yao, D Wu, G He… - Anti-cancer …, 2018 - journals.lww.com
Doxorubicin (DOX), also known as adriamycin, is a DNA topoisomerase II inhibitor and
belongs to the family of anthracycline anticancer drugs. DOX is used for the treatment of a …
belongs to the family of anthracycline anticancer drugs. DOX is used for the treatment of a …