A large variety of neuron models are used in theoretical and computational neuroscience,
and among these, single-compartment models are a popular kind. These models do not …

The initiation and propagation of action potentials (APs) places high demands on the
energetic resources of neural tissue. Each AP forces ATP-driven ion pumps to work harder …

Perhaps the most mature area of multi-scale systems biology is the modelling of the heart.
Current models are grounded in over fifty years of research in the development of …

In central neurons, the threshold for spike initiation can depend on the stimulus and varies
between cells and between recording sites in a given cell, but it is unclear what mechanisms …

We present detailed models of pyramidal cells from human neocortex, including models on
their excitatory synapses, dendritic spines, dendritic NMDA-and somatic/axonal Na+ spikes …

Recently, several two-dimensional spiking neuron models have been introduced, with the
aim of reproducing the diversity of electrophysiological features displayed by real neurons …

Neurons encode information in sequences of spikes, which are triggered when their
membrane potential crosses a threshold. In vivo, the spiking threshold displays large …

In most vertebrate neurons, action potentials are triggered at the distal end of the axon initial
segment (AIS). Both position and length of the AIS vary across and within neuron types, with …

Neurons spike when their membrane potential exceeds a threshold value. In central
neurons, the spike threshold is not constant but depends on the stimulation. Thus, input …

In cortical neurons, spikes are initiated in the axon initial segment. Seen at the soma, they
appear surprisingly sharp. A standard explanation is that the current coming from the axon …