Autophagy is a self-eating cellular catabolic pathway, through which long-lived proteins,
damaged organelles and misfolded proteins are degraded and recycled for the …

TC21, Rap, and Ral. Ras protein function is controlled by a guanosine triphosphate-
guanosine diphosphate (GTP-GDP) cycle that is regulated by at least 2 distinct classes of …

We have analyzed the interleukin-4 (IL-4)-triggered mechanisms implicated in cell survival
and show here that IL-4 deprivation induces apoptotic cell death but does not modulate Bcl …

In normal T-cell development, IL-7 plays a nonredundant role as an antiapoptic factor by
regulating Bcl-2 expression in pro-T cells. In the current study, we addressed the roles of IL …

Toxoplasma gondii is an opportunistic intracellular parasite that is highly prevalent in human
and warm-blooded animals throughout the world, leading to potentially severe congenital …

The importance of Ras proteins as crucial crossroads in cellular signaling pathways has
been well established. In spite of the elucidation of the mechanism of RAS activation by …

Growth factor deprivation is a physiological mechanism to induce apoptosis. We used an IL-
2-dependent murine T cell line to identify proteins that trigger apoptosis. Here we report the …

ABSTRACT AIM: To investigate the influence of esculentoside A (EsA) on immunological
function and its mechanism of antiinflammation. METHODS: Interleukin-1 production was …

Glycodelin A is one of the progesterone inducible endometrial factors that protect the fetal
semiallograft from maternal immune rejection. Our previous studies demonstrate that …

MAP kinase signaling pathways are important mediators of cellular responses to a wide
variety of stimuli. Signals pass along these pathways via kinase cascades in which three …