Significance: Oxygen is indispensable for aerobic life, but its utilization exposes cells and
tissues to oxidative stress; thus, tight regulation of cellular, tissue, and systemic oxygen …

Oxygen is vital for cellular metabolism; therefore, the hypoxic conditions encountered at high
altitude affect all physiological functions. Acute hypoxia activates the adrenergic system and …

The (patho-) physiological responses to hypoxia are highly heterogeneous between
individuals. In this review, we focused on the roles of sex differences, which emerge as …

Sex differences in physiological responses to various stressors, including exercise, have
been well documented. However, the specific impact of these differences on exposure to …

With the advancement of in vivo magnetic resonance imaging (MRI) technique, more
detailed information about the human brain at high altitude (HA) has been revealed. The …

Highlights What are the main findings? Highly functioning adults with a sedentary lifestyle
benefit physically and mentally from forest therapy and mountain hiking. Women …

Ramchandani, Rashi, Ioana Tereza Florica, Zier Zhou, Aziz Alemi, and Adrian Baranchuk.
Review of athletic guidelines for high-altitude training and acclimatization. High Alt Med Biol …

Although peripheral artery disease (PAD) primarily affects large arteries outside the brain,
PAD is also associated with elevated cerebral vulnerabilities, including greater risks for …

Aim Under hypobaric hypoxia (HH), the heart triggers various defense mechanisms
including metabolic remodeling against lack of oxygen. Mitofusin 2 (MFN2), located at the …

Introduction: Worldwide, more than 5.7% of the population reside above 1,500 m of
elevation. It has been hypothesized that acute short-term hypoxia exposure could increase …