Hepatitis E virus: Infection beyond the liver?

S Pischke, J Hartl, SD Pas, AW Lohse, BC Jacobs… - Journal of …, 2017 - Elsevier
Hepatitis E virus (HEV) infections are not limited to the liver but may also affect other organs.
Several diseases, including Guillain-Barré syndrome, neuralgic amyotrophy …

Cross-priming in health and disease

C Kurts, BWS Robinson, PA Knolle - Nature Reviews Immunology, 2010 - nature.com
Cross-priming is an important mechanism to activate cytotoxic T lymphocytes (CTLs) for
immune defence against viruses and tumours. Although it was discovered more than 25 …

Advances in the diagnosis, pathogenesis, and management of autoimmune hepatitis

AJ Czaja, MP Manns - Gastroenterology, 2010 - Elsevier
Autoimmune hepatitis (AIH) is characterized by chronic inflammation of the liver, interface
hepatitis (based on histologic examination), hypergammaglobulinemia, and production of …

Differential CD4+ and CD8+ T-cell responsiveness in hepatitis C virus infection

KM Chang, R Thimme, JJ Melpolder, D Oldach… - Hepatology, 2001 - Elsevier
This study was performed to compare the vigor and phenotype of virus-specific CD4+ and
CD8+ T-cell responses in patients with different virologic and clinical outcomes after …

SARS-CoV-2 Infects Human ACE2-Negative Endothelial Cells through an αvβ3 Integrin-Mediated Endocytosis Even in the Presence of Vaccine-Elicited Neutralizing …

A Bugatti, F Filippini, M Bardelli, A Zani, P Chiodelli… - Viruses, 2022 - mdpi.com
Integrins represent a gateway of entry for many viruses and the Arg-Gly-Asp (RGD) motif is
the smallest sequence necessary for proteins to bind integrins. All Severe Acute Respiratory …

Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for …

MS von Bergwelt-Baildon… - Blood, The Journal …, 2002 - ashpublications.org
CD40 engagement is the major signal that induces B cells to efficiently present antigen to T
cells. We previously demonstrated that human peripheral blood–derived CD40-activated B …

Autoimmune hepatitis

P Obermayer-Straub, CP Strassburg, MP Manns - Journal of hepatology, 2000 - Elsevier
Autoimmune hepatitis (AIH) is a rare disease, characterized by female predominance,
hypergammaglobulinemia, autoantibodies, association with HLA DR3 and HLA DR4 and a …

Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection

M Holdener, E Hintermann, M Bayer, A Rhode… - The Journal of …, 2008 - rupress.org
Autoimmune liver diseases, such as autoimmune hepatitis (AIH) and primary biliary
cirrhosis, often have severe consequences for the patient. Because of a lack of appropriate …

Cell-mediated immunity and the outcome of hepatitis C virus infection

NH Shoukry, AG Cawthon, CM Walker - Annu. Rev. Microbiol., 2004 - annualreviews.org
▪ Abstract The hepatitis C virus (HCV) infects approximately three percent of the world's
population. Some individuals resolve the infection spontaneously, but the majority develop …

[PDF][PDF] Cytochrome P450IID6‐specific CD8 T cell immune responses mirror disease activity in autoimmune hepatitis type 2

MS Longhi, MJ Hussain, DP Bogdanos, A Quaglia… - …, 2007 - Wiley Online Library
Abstract Autoimmune hepatitis type 2 (AIH‐2) is a severe organ‐specific disorder
characterized by liver kidney microsomal antibody type 1 targeting cytochrome P4502D6 …