[HTML][HTML] Mechanisms of insulin resistance related to white, beige, and brown adipocytes

MP Czech - Molecular metabolism, 2020 - Elsevier
Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Brown adipose tissue-derived metabolites and their role in regulating metabolism

K Ziqubu, PV Dludla, SE Mabhida, BU Jack, S Keipert… - Metabolism, 2024 - Elsevier
The discovery and rejuvenation of metabolically active brown adipose tissue (BAT) in adult
humans have offered a new approach to treat obesity and metabolic diseases. Beyond its …

Lipolysis regulates major transcriptional programs in brown adipocytes

LK Markussen, EA Rondini, OS Johansen… - Nature …, 2022 - nature.com
Abstract β-Adrenergic signaling is a core regulator of brown adipocyte function stimulating
both lipolysis and transcription of thermogenic genes, thereby expanding the capacity for …

Aifm2, a NADH oxidase, supports robust glycolysis and is required for cold-and diet-induced thermogenesis

HP Nguyen, D Yi, F Lin, JA Viscarra, C Tabuchi, K Ngo… - Molecular cell, 2020 - cell.com
Brown adipose tissue (BAT) is highly metabolically active tissue that dissipates energy via
UCP1 as heat, and BAT mass is correlated negatively with obesity. The presence of …

Rna M6a Methylation Regulates Glycolysis of Beige Fat and Contributes to Systemic Metabolic Homeostasis

Y Li, Y Zhang, T Zhang, X Ping, D Wang… - Advanced …, 2023 - Wiley Online Library
Abstract N6‐methyladenosine (m6A) modification has been implicated in the progression of
obesity and metabolic diseases. However, its impact on beige fat biology is not well …

[HTML][HTML] UCP1-dependent and UCP1-independent metabolic changes induced by acute cold exposure in brown adipose tissue of mice

Y Okamatsu-Ogura, M Kuroda, R Tsutsumi, A Tsubota… - Metabolism, 2020 - Elsevier
Background Brown adipose tissue (BAT) is a site of metabolic thermogenesis mediated by
mitochondrial uncoupling protein 1 (UCP1) and represents a target for a therapeutic …

Energy metabolism in brown adipose tissue

Z Wang, QA Wang, Y Liu, L Jiang - The FEBS Journal, 2021 - Wiley Online Library
Brown adipose tissue (BAT) is well known to burn calories through uncoupled respiration,
producing heat to maintain body temperature. This 'calorie wasting'feature makes BAT a …

Brown adipocyte glucose metabolism: a heated subject

MK Hankir, M Klingenspor - EMBO reports, 2018 - embopress.org
The energy expending and glucose sink properties of brown adipose tissue (BAT) make it
an attractive target for new obesity and diabetes treatments. Despite decades of research …

IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis

S Yan, M Kumari, H Xiao, C Jacobs… - The Journal of …, 2021 - Am Soc Clin Investig
Adipose thermogenesis is repressed in obesity, reducing the homeostatic capacity to
compensate for chronic overnutrition. Inflammation inhibits adipose thermogenesis, but little …

[HTML][HTML] In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate

SM Jung, WG Doxsey, J Le, JA Haley, L Mazuecos… - Cell reports, 2021 - cell.com
Active brown adipose tissue (BAT) consumes copious amounts of glucose, yet how glucose
metabolism supports thermogenesis is unclear. By combining transcriptomics …