Metal and metal oxide nanoparticles have been widely used in catalytic, electronic and
biomedical fields. It is necessary to investigate their toxicity and potential hazards to human …

Complex tissue regeneration involves exquisitely coordinated proliferation and patterning of
adult cells after severe injury or amputation. Certain lower vertebrates such as urodele …

INTRODUCTION Organisms live by means of the complex, dynamic, three-dimensional (3D)
interplay between millions of components, from the molecular to the multicellular. Visualizing …

Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function.
To explore circRNAs systematically, we sequenced and computationally analysed human …

When a behavior repeatedly fails to achieve its goal, animals often give up and become
passive, which can be strategic for preserving energy or regrouping between attempts. It is …

Brain function relies on communication between large populations of neurons across
multiple brain areas, a full understanding of which would require knowledge of the time …

A fundamental question in neuroscience is how entire neural circuits generate behaviour
and adapt it to changes in sensory feedback. Here we use two-photon calcium imaging to …

Hundreds of human genes are associated with neurological diseases, but translation into
tractable biological mechanisms is lagging. Larval zebrafish are an attractive model to …

RNA-guided endonucleases (RGENs), derived from the prokaryotic Type II CRISPR-Cas
system, enable targeted genome modification in cells and organisms. Here we describe the …

Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are
permitted to become neurons within domains defined by proneural gene expression …