Neurofilament proteins as biomarkers to monitor neurological diseases and the efficacy of therapies
Biomarkers of neurodegeneration and neuronal injury have the potential to improve
diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy …
diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy …
[HTML][HTML] Blood-brain barrier: from physiology to disease and back
MD Sweeney, Z Zhao, A Montagne… - Physiological …, 2018 - journals.physiology.org
The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …
pathogens from entering the brain. At the same time, the BBB regulates transport of …
[HTML][HTML] Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
MD Sweeney, AP Sagare, BV Zlokovic - Nature Reviews Neurology, 2018 - nature.com
The blood–brain barrier (BBB) is a continuous endothelial membrane within brain
microvessels that has sealed cell-to-cell contacts and is sheathed by mural vascular cells …
microvessels that has sealed cell-to-cell contacts and is sheathed by mural vascular cells …
Diagnostic value of cerebrospinal fluid neurofilament light protein in neurology: a systematic review and meta-analysis
C Bridel, WN Van Wieringen, H Zetterberg… - JAMA …, 2019 - jamanetwork.com
Importance Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a
number of neurological conditions compared with healthy controls (HC) and is a candidate …
number of neurological conditions compared with healthy controls (HC) and is a candidate …
Microglial cells: the main HIV-1 reservoir in the brain
C Wallet, M De Rovere, J Van Assche… - Frontiers in cellular …, 2019 - frontiersin.org
Despite efficient combination of the antiretroviral therapy (cART), which significantly
decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been …
decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been …
[HTML][HTML] HIV-associated neurocognitive disorder—pathogenesis and prospects for treatment
In the past two decades, several advancements have improved the care of HIV-infected
individuals. Most importantly, the development and deployment of combination antiretroviral …
individuals. Most importantly, the development and deployment of combination antiretroviral …
The multifaceted role of neurofilament light chain protein in non-primary neurological diseases
The advancing validation and exploitation of CSF and blood neurofilament light chain
protein as a biomarker of neuroaxonal damage has deeply changed the current diagnostic …
protein as a biomarker of neuroaxonal damage has deeply changed the current diagnostic …
Blood-based NfL: a biomarker for differential diagnosis of parkinsonian disorder
Objective: To determine if blood neurofilament light chain (NfL) protein can discriminate
between Parkinson disease (PD) and atypical parkinsonian disorders (APD) with equally …
between Parkinson disease (PD) and atypical parkinsonian disorders (APD) with equally …
Plasma concentration of the neurofilament light protein (NFL) is a biomarker of CNS injury in HIV infection: a cross-sectional study
M Gisslén, RW Price, U Andreasson, N Norgren… - …, 2016 - thelancet.com
Background Cerebrospinal fluid (CSF) neurofilament light chain protein (NFL) is a sensitive
marker of neuronal injury in a variety of neurodegenerative conditions, including the CNS …
marker of neuronal injury in a variety of neurodegenerative conditions, including the CNS …
Prevalence of HIV-associated neurocognitive disorders in the Multicenter AIDS Cohort Study
Objective: To evaluate the frequency of HIV-associated neurocognitive disorder (HAND) in
HIV+ individuals and determine whether the frequency of HAND changed over 4 years of …
HIV+ individuals and determine whether the frequency of HAND changed over 4 years of …