[HTML][HTML] The ABC gene family in arthropods: comparative genomics and role in insecticide transport and resistance
W Dermauw, T Van Leeuwen - Insect biochemistry and molecular biology, 2014 - Elsevier
About a 100 years ago, the Drosophila white mutant marked the birth of Drosophila genetics.
The white gene turned out to encode the first well studied ABC transporter in arthropods …
The white gene turned out to encode the first well studied ABC transporter in arthropods …
Interferon-γ: an overview of signals, mechanisms and functions
Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …
transcriptional regulation of immunologically relevant genes. This article reviews the current …
The human ATP-binding cassette (ABC) transporter superfamily
The transport of specific molecules across lipid membranes is an essential function of all
living organisms and a large number of specific transporters have evolved to carry out this …
living organisms and a large number of specific transporters have evolved to carry out this …
Cellular responses to interferon-γ
U Boehm, T Klamp, M Groot… - Annual review of …, 1997 - annualreviews.org
▪ Abstract The phytohemagglutinin-induced virus-inhibitor may, however, be produced in
white cells in response to a stimulation of cellular RNA synthesis and may be a feedback …
white cells in response to a stimulation of cellular RNA synthesis and may be a feedback …
How cells respond to interferons
GR Stark, IM Kerr, BRG Williams… - Annual review of …, 1998 - annualreviews.org
Interferons play key roles in mediating antiviral and antigrowth responses and in modulating
immune response. The main signaling pathways are rapid and direct. They involve tyrosine …
immune response. The main signaling pathways are rapid and direct. They involve tyrosine …
The ubiquitin–proteasome system in immune cells
G Çetin, S Klafack, M Studencka-Turski, E Krüger… - Biomolecules, 2021 - mdpi.com
The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal
protein degradation system. Thanks to its unique capacity of eliminating old, damaged …
protein degradation system. Thanks to its unique capacity of eliminating old, damaged …
Mechanisms of multidrug resistance in cancer
JP Gillet, MM Gottesman - Multi-drug resistance in cancer, 2010 - Springer
The development of multidrug resistance (MDR) to chemotherapy remains a major
challenge in the treatment of cancer. Resistance exists against every effective anticancer …
challenge in the treatment of cancer. Resistance exists against every effective anticancer …
Immune response in mice that lack the interferon-γ receptor
Interferon-γ (IFN-γ) exerts pleiotropic effects, including antiviral activity, stimulation of
macrophages and natural killer cells, and increased expression of major histocompatibility …
macrophages and natural killer cells, and increased expression of major histocompatibility …
Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters
Abstract ADRENOLEUKODYSTROPHY (ALD) is an X-linked disease affecting 1/20,000
males either as cerebral ALD in childhood or as adrenomyeloneuropathy (AMN) in adults1 …
males either as cerebral ALD in childhood or as adrenomyeloneuropathy (AMN) in adults1 …
Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures
S Goodbourn, L Didcock… - Journal of general …, 2000 - microbiologyresearch.org
To establish infections in vivo, viruses must replicate in the face of powerful immune defence
mechanisms including those induced by interferons (IFNs). The effectiveness of the IFN …
mechanisms including those induced by interferons (IFNs). The effectiveness of the IFN …