A great many cell types are necessary for the myriad capabilities of complex, multicellular
organisms. One interesting aspect of this diversity of cell type is that many cells in diploid …

Insects are a highly successful group of animals that inhabit almost every habitat and
environment on Earth. Part of their success is due to a rapid and highly effective immune …

In endoreplication cell cycles, known as endocycles, cells successively replicate their
genomes without segregating chromosomes during mitosis and thereby become polyploid …

Polyploid cells have genomes that contain multiples of the typical diploid chromosome
number and are found in many different organisms. Studies in a variety of animal and plant …

The Hippo signaling pathway regulates organ size and tissue homeostasis from Drosophila
to mammals. Central to this pathway is a kinase cascade wherein Hippo (Hpo), in complex …

Polyploid cells, which contain multiple copies of the typically diploid genome, are
widespread in plants and animals. Polyploidization can be developmentally programmed or …

Oogenesis is a complex developmental process that involves spatiotemporally regulated
coordination between the germline and supporting, somatic cell populations. This process …

Invertebrates are the protagonists of a recent paradigm shift because they now show that
vertebrates are not the only group with immune memory. This review discusses the concept …

Signaling through the transmembrane receptor Notch is widely used throughout animal
development and is a major regulator of cell proliferation and differentiation. During …

We have identified Rabconnectin-3α and β (Rbcn-3A and B) as two regulators of Notch
signaling in Drosophila. We found that, in addition to disrupting Notch signaling, mutations in …