Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention
X Zhu, Z Chen, W Shen, G Huang, JM Sedivy… - Signal transduction and …, 2021 - nature.com
Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …
General perceptions and experimental evidence pinpoint that the decline of physical …
Epigenetic clock: A promising biomarker and practical tool in aging
R Duan, Q Fu, Y Sun, Q Li - Ageing Research Reviews, 2022 - Elsevier
As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …
Single-cell DNA methylation and 3D genome architecture in the human brain
Delineating the gene-regulatory programs underlying complex cell types is fundamental for
understanding brain function in health and disease. Here, we comprehensively examined …
understanding brain function in health and disease. Here, we comprehensively examined …
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
S Horvath, K Raj - Nature reviews genetics, 2018 - nature.com
Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …
[HTML][HTML] An epigenetic biomarker of aging for lifespan and healthspan
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …
generation of epigenetic biomarkers of aging were developed using chronological age as a …
[HTML][HTML] Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
Behavioral and lifestyle factors have been shown to relate to a number of health-related
outcomes, yet there is a need for studies that examine their relationship to molecular aging …
outcomes, yet there is a need for studies that examine their relationship to molecular aging …
DNA methylation and healthy human aging
The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
DNA methylation age of human tissues and cell types
S Horvath - Genome biology, 2013 - Springer
Background It is not yet known whether DNA methylation levels can be used to accurately
predict age across a broad spectrum of human tissues and cell types, nor whether the …
predict age across a broad spectrum of human tissues and cell types, nor whether the …
Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals
Differential DNA methylation in the brain is associated with many psychiatric diseases, but
access to brain tissues is essentially limited to postmortem samples. The use of surrogate …
access to brain tissues is essentially limited to postmortem samples. The use of surrogate …