What is known and objective Genetic polymorphism is one of the most important factors
responsible for interindividual and interethnic variability in drug response. Studies in major …

Precision medicine gives individuals tailored medical treatment, with the genotype
determining the therapeutic strategy, the appropriate dosage, and the likelihood of benefit or …

Asian populations are under-represented in human genomics research. Here, we
characterize clinically significant genetic variation in 9051 genomes representing East …

Introduction Racial and ethnic categories are frequently used in pharmacogenetics literature
to stratify patients; however, these categories can be inconsistent across different studies. To …

Genetic variation has a significant impact on an individual's metabolism and response to a
wide range of medications. The cytochrome P450 family of enzymes are key determinants in …

Abstract Cytochrome P450 (CYP) 2D6 is present in less than about 2% of all CYP enzymes
in the liver, but it is involved in the metabolism of about 25% of currently used drugs …

Whole-genome sequencing and whole-exome sequencing have proven valuable for
diagnosing inherited diseases, particularly in children. However, usage of sequencing data …

Drug pharmacokinetics (PK) is influenced by multiple intrinsic and extrinsic factors, among
which concomitant medications are responsible for drug–drug interactions (DDIs) that may …

Abstract Cytochrome P450 (CYP450) is a group of enzymes that play an essential role in
Phase I metabolism, with 57 functional genes classified into 18 families in the human …

Objective Pharmacogenomics (PGx) is a clinically significant factor in the safe and
efficacious use of medicines. While PGx knowledge is abundant for other populations, there …