For the past decade, cellular oncogenes have attracted the attention of biologists intent on
understanding the molecular origins of cancer. As the present decade unfolds, oncogenes …

THYROID follicular cell tumors present a unique model for the study of genetic and
environmental factors predisposing to benign nodule formation, well differentiated malignant …

Although it is generally believed that the product of the retinoblastoma susceptibility gene
(RB7) is an important regulator of cell proliferation, the biochemical mechanism for its action …

The retinoblastoma gene, a prototypic tumour-suppressor gene, encodes a nuclear
phosphoprotein (Rb). To understand better the role of Rb in development and in …

The adenovirus E1A gene product, the simian virus 40 large tumor antigen, and the human
papillomavirus E7 protein share a short amino acid sequence that constitutes a domain …

The study of female preferences and the evolution of male traits has until recently centered
on genetic coevolutionary mechanisms. An alternative mechanism posits that a preference …

Summary p105-RB is the product of the retinoblastoma tumor suppressor gene. It is a
nuclear phosphoprotein hypothesized to act as an inhibitor of cellular proliferation, yet …

Recent experiments have shown that the E2F transcription factor is in a complex with the
RB1 gene product. The E2F-pRB complex can be reconstituted in an in vitro assay using a …

Hematogenous metastasis requires the arrest and extravasation of blood-borne tumor cells,
possibly involving direct adhesive interactions with vascular endothelium. Cytokine …

The growth-suppressive function of the retinoblastoma gene product, RB, has been ascribed
to the underphosphorylated RB form that prevails during Gl phase in the cell cycle. We show …