[HTML][HTML] Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer

F Wu, J Yang, J Liu, Y Wang, J Mu, Q Zeng… - … and Targeted Therapy, 2021 - nature.com
To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

[HTML][HTML] Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

NF‐κB signaling in inflammation and cancer

T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?

S Mirzaei, A Zarrabi, F Hashemi, A Zabolian, H Saleki… - Cancer Letters, 2021 - Elsevier
The nuclear factor-kappaB (NF-κB) signaling pathway is considered as a potential
therapeutic target in cancer therapy. It has been well established that transcription factor NF …

[HTML][HTML] NF-κB signaling in macrophages: dynamics, crosstalk, and signal integration

MG Dorrington, IDC Fraser - Frontiers in immunology, 2019 - frontiersin.org
The nuclear factor-κB (NF-κB) signaling pathway is one of the best understood immune-
related pathways thanks to almost four decades of intense research. NF-κB signaling is …

Role of the NFκB-signaling pathway in cancer

L Xia, S Tan, Y Zhou, J Lin, H Wang… - OncoTargets and …, 2018 - Taylor & Francis
Cancer is a group of cells that malignantly grow and proliferate uncontrollably. At present,
treatment modes for cancer mainly comprise surgery, chemotherapy, radiotherapy …

NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

S Mirzaei, S Saghari, F Bassiri, R Raesi… - Journal of cellular …, 2022 - Wiley Online Library
Metastasis of tumor cells is a complex challenge and significantly diminishes the overall
survival and prognosis of cancer patients. The epithelial‐to‐mesenchymal transition (EMT) …

[HTML][HTML] Role of miRNA-regulated cancer stem cells in the pathogenesis of human malignancies

AQ Khan, EI Ahmed, NR Elareer, K Junejo, M Steinhoff… - Cells, 2019 - mdpi.com
Recent biomedical discoveries have revolutionized the concept and understanding of
carcinogenesis, a complex and multistep phenomenon which involves accretion of genetic …

[HTML][HTML] Small molecule NF-κB pathway inhibitors in clinic

V Ramadass, T Vaiyapuri, V Tergaonkar - International journal of …, 2020 - mdpi.com
Nuclear factor kappa B (NF-κB) signaling is implicated in all major human chronic diseases,
with its role in transcription of hundreds of gene well established in the literature. This has …

[HTML][HTML] Neuroinflammation in schizophrenia: the role of nuclear factor kappa B

CE Murphy, AK Walker, CS Weickert - Translational psychiatry, 2021 - nature.com
Neuroinflammation, particularly in the dorsolateral prefrontal cortex, is well-established in a
subset of people with schizophrenia, with significant increases in inflammatory markers …