Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

As an essential micronutrient, manganese (Mn) participates in various physiological
processes and plays important roles in host immune system, hematopoiesis, endocrine …

Importance Glioblastoma is the most lethal primary brain cancer. Clinical outcomes for
glioblastoma remain poor, and new treatments are needed. Objective To investigate …

The strategy of combining a vaccine with immune checkpoint inhibitors has been widely
investigated in cancer management, but the complete response rate for this strategy is still …

Abstract cGAS-STING pathway is a key DNA-sensing machinery and emerges as a
promising target to overcome the immunoresistance of solid tumors. Here we describe a …

Cancer immunotherapy has revolutionised cancer treatment, with immune checkpoint
blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming standard of …

Because the tumour microenvironment is typically immunosuppressive, the release of
tumour antigens mediated by radiotherapy or chemotherapy does not sufficiently activate …

CD8+ cytotoxic T lymphocytes (CTLs) are preferred immune cells for targeting cancer.
During cancer progression, CTLs encounter dysfunction and exhaustion due to …

Immunotherapy that harnesses the human immune system to fight cancer has received
widespread attention and become a mainstream strategy for cancer treatment. Cancer …

Cervical cancer is one of the most common cancers threatening women's health, and the
persistent infection of high-risk human papillomavirus (HPV) is closely related to the …