Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis …

Immunotherapy with checkpoint blockade induces rapid and durable immune control of
cancer in some patients and has driven a monumental shift in cancer treatment. Neoantigen …

Natural killer (NK) cells, a crucial component of the innate immune system, have long been
of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is …

Immuno-oncology is an emerging field that has revolutionized cancer treatment. Most
immunomodulatory strategies focus on enhancing T cell responses, but there has been a …

Natural killer (NK) cells are a population of innate lymphoid cells playing a pivotal role in
host immune responses against infection and tumor growth. These cells have a powerful …

Natural killer (NK) cells are innate lymphocytes that provide critical host defense against
pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells …

Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In
cancer, ILC2s can harbor both pro-tumorigenic and anti-tumorigenic functions, but we know …

The metastatic spread of malignant cells to distant anatomical locations is a prominent
cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms …

Avoiding destruction by immune cells is a hallmark of cancer, yet how tumors ultimately
evade control by natural killer (NK) cells remains incompletely defined. Using global …