Prostate cancer exerts a greater toll on African American men than on White men of
European descent (hereafter referred to as European American men): the disparity in …

Black men with prostate cancer have historically had worse outcomes than white men with
prostate cancer. The causes of this disparity in outcomes are multi-factorial, but a potential …

Background: Ancestry is often viewed as a more objective and less objectionable population
descriptor than race or ethnicity. Perhaps reflecting this, usage of the term “ancestry” is …

Neuroblastoma (NB) arises from oncogenic disruption of neural crest (NC) differentiation.
Treatment with retinoic acid (RA) to induce differentiation has improved survival in some NB …

The liver plays a significant role in regulating a wide range of metabolic, homeostatic, and
host-defense functions. However, the impact of liver injury on the host's ability to control …

Background: Hypertension is the largest risk factor affecting global mortality. Despite
available medications, uncontrolled hypertension is on the rise, whereby there is an urgent …

Objective The liver is the primary internal metabolic organ that coordinates whole body
energy homeostasis in response to feeding and fasting. Genetic ablation or pharmacological …

Background Respiratory tract microbial dysbiosis can exacerbate inflammation and
conversely inflammation may cause dysbiosis. Dysbiotic microbiome metabolites may lead …

Approximately one-third of endocrine-treated women with estrogen receptor alpha–positive
(ER+) breast cancers are at risk of recurrence due to intrinsic or acquired resistance. Thus, it …

Background Non‐small cell lung cancer (NSCLC) comprises the majority (~ 85%) of all lung
tumors, with lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) being the …