Osteosarcoma (OS) is a bone tumor of mesenchymal origin, most frequently occurring
during the rapid growth phase of long bones, and usually located in the epiphyseal growth …

Simple Summary Loss of function of the retinoblastoma gene (RB1) is the rate-limiting step
in the initiation of both the hereditary and sporadic forms of retinoblastoma tumor …

How stem cells give rise to epidermis is unclear despite the crucial role the epidermis plays
in barrier and appendage formation. Here we use single cell-RNA sequencing to interrogate …

Loss-of-function mutations at the retinoblastoma (RB1) gene are associated with increased
mortality, metastasis, and poor therapeutic outcome in several cancers, including …

Retinoblastoma is an aggressive childhood cancer of the developing retina that initiates by
biallelic RB1 gene inactivation. Tumor progression in retinoblastoma is driven by …

The major challenges in Osteosarcoma (OS) therapy are its heterogeneity and drug
resistance. The development of new therapeutic approaches to overcome the major growth …

Dormancy is a potential way for tumors to develop drug resistance and escape treatment.
However, the mechanisms involved in cancer dormancy remain poorly understood. This is …

Objective To investigate the role of hsa_circ_0008934 in osteosarcoma and the molecular
mechanism involved in the regulation of the occurrence and development of osteosarcoma …

Medulloblastoma is a malignant pediatric tumor that arises from neural progenitors in the
cerebellum. Despite a five-year survival rate of~ 70%, nearly all patients incur adverse side …

Bone contributes to the maintenance of vital biological activities. At the cellular level,
multiple types of skeletal cells, including skeletal stem and progenitor cells (SSPCs) …