Addition of multiple molecularly targeted agents to the existing armamentarium of
chemotherapeutics and radiotherapies represents a significant advance in the management …

Cancer is a multi-step disease caused by the accumulation of genetic mutations and/or
epigenetic changes, and is the biggest challenge around the world. Cytokines, including …

Acute traumatic spinal cord injury is a devastating event without effective therapeutic
approach. The feeble plasticity of spinal cord microvascular endothelial cells (SCMECs) …

Ideal biomaterials for bone tissue engineering should have the capability to guide the
osteogenic differentiation of mesenchymal stem cells and, at the same time, to stimulate …

Tumorigenesis is a multistep process characterized by the acquisition of genetic and
epigenetic alterations. During the course of malignancy development, tumor cells acquire …

The biological role of miR-500a-5p has not yet been reported in the context of colorectal
cancer (CRC). Here, we show that miR-500a-5p expression is decreased in CRC tissues …

Simple Summary Cancer is a global health problem with severe consequences. Certain
genes, known as transcription factors (TFs), are overactive in many tumors. Targeting these …

We examined the role of microRNAs (miRNAs) in targeting the stromal-derived factor
1α/CXCR4 (SDF-1α/CXCR4) axis to overcome chemoresistance of AML cells. Microarray …

A growing number of failing clinical trials for cancer therapy are substantiating the need to
upgrade the current practice in culturing tumor cells and modeling tumor angiogenesis in …

Emerging lines of evidence have shown that extracellular vesicles (EVs) mediate cell-to-cell
communication by exporting encapsulated materials, such as microRNAs (miRNAs), to …