Dementia is a frequent problem encountered in advanced stages of Parkinson disease (PD).
In recent years, research has focused on the pre-dementia stages of cognitive impairment in …

This article reviews and summarizes 200 years of Parkinson's disease. It comprises a
relevant history of Dr. James Parkinson's himself and what he described accurately and …

Dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD), although
sharing many clinical, neurochemical and morphological features, according to DSM-5, are …

Biomarkers in whichever modality are tremendously important in diagnosing of disease,
tracking disease progression and clinical trials. This applies in particular for disorders with a …

A common finding in human functional brain-imaging studies is that damage to neural
systems paradoxically results in enhanced functional connectivity between network regions …

Functional neuroimaging techniques provide important insight into the pathophysiology of
neurodegenerative disorders such as Parkinson's disease (PD) in-vivo. Recently, resting …

Mild cognitive impairment (PD-MCI) and dementia (PDD) are among the most frequent non-
motor symptoms in Parkinson's disease (PD). PD-MCI is six times more likely than age …

No medications are proven to slow the progression of Parkinson disease (PD). Of special
concern with longer-standing PD is cognitive decline, as well as motor symptoms …

Cognitive decline is one of the most frequent and disabling nonmotor features of Parkinson's
disease. Around 30% of patients with Parkinson's disease experience mild cognitive …

Resting-state functional magnetic resonance imaging (RS-fMRI) studies have been
extensively applied to analyze the pathophysiology of neurodegenerative disorders such as …