The discovery of the rapid antidepressant effects of the dissociative anaesthetic ketamine,
an uncompetitive N-Methyl-D-Aspartate receptor antagonist, is arguably the most important …

Caveolins (Cavs) are integrated plasma membrane proteins that are complex signaling
regulators with numerous partners and whose activity is highly dependent on cellular …

G-protein-coupled receptors (GPCRs) play critical roles in regulating physiological
processes ranging from neurotransmission to cardiovascular function. Current methods for …

Background Major depressive disorder (MDD) is a highly heterogenous disease, both in
terms of clinical profiles and pathobiological alterations. Recently, immunometabolic …

Ketamine produces rapid and robust antidepressant effects in depressed patients within
hours of administration, often when traditional antidepressant compounds have failed to …

Membrane-integral adenylyl cyclases (ACs) are key enzymes in mammalian heterotrimeric
GTP-binding protein (G protein)–dependent signal transduction, which is important in many …

In contrast to healthy controls, the heterotrimeric G protein, Gsalpha (Gsα) is ensconced
predominantly in lipid rafts in subjects with major depressive disorder (MDD) resulting in …

Introduction: Statins have been widely used in clinical practice; however, the association
between statin use and depression is complex as research findings have been mixed. We …

Tissue homeostasis requires regulation of cell–cell communication, which relies on
signaling molecules and cell contacts. In skin epidermis, keratinocytes secrete factors …

Astrocytes are major glial cells that play critical roles in brain homeostasis. Abnormalities in
astrocytic functions can lead to brain disorders. Astrocytes also respond to injury and …