The roles of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as
core components of the machinery that drives cell cycle progression are well established …

Cyclin-dependent kinases (Cdks) are serine/threonine kinases and their catalytic activities
are modulated by interactions with cyclins and Cdk inhibitors (CKIs). Close cooperation …

The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent
kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and …

Despite significant advances in early detection and treatment, breast cancer still remains a
major cause of morbidity and mortality for women. Our understanding of the molecular …

Aggressive cancers such as glioblastoma (GBM) contain intermingled apoptotic cells
adjacent to proliferating tumor cells. Nonetheless, intercellular signaling between apoptotic …

Cyclin D1, and to a lesser extent the other D-type cyclins, is frequently deregulated in cancer
and is a biomarker of cancer phenotype and disease progression. The ability of these …

Since their characterization as conserved modules that regulate progression through the
eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are …

In contrast to its close homolog CDK4, the cell cycle kinase CDK6 is expressed at high
levels in lymphoid malignancies. In a model for p185 BCR-ABL+ B-acute lymphoid …

Cyclin D1 is a component of the core cell cycle machinery. Abnormally high levels of cyclin
D1 are detected in many human cancer types. To elucidate the molecular functions of cyclin …

The mammalian cell cycle is driven by a complex of cyclins and their associated cyclin-
dependent kinases (CDKs). Abnormal dysregulation of cyclin-CDK is a hallmark of cancer. D …