Maleimide chemistry stands out in the bioconjugation toolbox by virtue of its synthetic
accessibility, excellent reactivity, and practicability. The second‐generation of clinically …

Most cancer drugs are designed to interfere with one or more events in cell proliferation or
survival. As healthy cells may also need to proliferate and avoid apoptosis, anticancer …

Our understanding of the complex molecular processes of living organisms at the molecular
level is growing exponentially. This knowledge, together with a powerful arsenal of tools for …

Therapeutic interventions to harness the immune system against tumor cells have provided
mixed results in the past for several solid tumors and hematologic malignancies. However …

The adoptive transfer of autologous T cells engineered to express a chimeric antigen
receptor (CAR) has emerged as a promising cancer therapy. Despite impressive clinical …

Virtually all natural proteins are built from only 20 amino acids, and while this makes
possible all the functions they perform, the ability to encode other amino acids selected for …

Bioconjugates represent an emerging class of medicines, which offer therapeutic
opportunities overtaking those of the individual components. Many novel bioconjugates …

As antibody–drug conjugates have become a very important modality for cancer therapy,
many site-specific conjugation approaches have been developed for generating …

DNA–protein conjugates are important in bioanalytical chemistry, molecular diagnostics and
bionanotechnology, as the DNA provides a unique handle to identify, functionalize or …

Effective drug delivery systems that can systematically and selectively transport payloads to
disease cells remain a challenge. Here, a targeting ligand‐modified DNA origami …