The rapid and enthusiastic adoption of single-cell RNA sequencing (scRNA-seq) has
demonstrated that this technology is far more than just another way to perform transcriptome …

Droplet microfluidics has revolutionized the study of single cells. The ability to
compartmentalize cells within picoliter droplets in microfluidic devices has opened up a wide …

Cell differentiation and function are regulated across multiple layers of gene regulation,
including modulation of gene expression by changes in chromatin accessibility. However …

By engaging angiotensin-converting enzyme 2 (ACE2 or Ace2), the novel pathogenic
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades host cells and …

Background Single-cell transcriptomics is rapidly advancing our understanding of the
cellular composition of complex tissues and organisms. A major limitation in most analysis …

Neuronal types in the central nervous system differ dramatically in their resilience to injury or
other insults. Here we studied the selective resilience of mouse retinal ganglion cells …

Background Recent innovations in single-cell Assay for Transposase Accessible Chromatin
using sequencing (scATAC-seq) enable profiling of the epigenetic landscape of thousands …

Recent advances in single-cell technologies and integration algorithms make it possible to
construct comprehensive reference atlases encompassing many donors, studies, disease …

Visualization of the transcriptome in situ has proven to be a valuable tool in exploring single-
cell RNA-sequencing data, providing an additional spatial dimension to investigate …

Single-cell gene expression (transcriptomics) data are becoming robust and abundant, and
are increasingly used to track organisms along their life-course. This allows investigation …