The extracellular matrix in development
DAC Walma, KM Yamada - Development, 2020 - journals.biologists.com
As the crucial non-cellular component of tissues, the extracellular matrix (ECM) provides
both physical support and signaling regulation to cells. Some ECM molecules provide a …
both physical support and signaling regulation to cells. Some ECM molecules provide a …
Mechanical state transitions in the regulation of tissue form and function
Y Mao, SA Wickström - Nature Reviews Molecular Cell Biology, 2024 - nature.com
From embryonic development, postnatal growth and adult homeostasis to reparative and
disease states, cells and tissues undergo constant changes in genome activity, cell fate …
disease states, cells and tissues undergo constant changes in genome activity, cell fate …
Growth anisotropy of the extracellular matrix shapes a developing organ
Final organ size and shape result from volume expansion by growth and shape changes by
contractility. Complex morphologies can also arise from differences in growth rate between …
contractility. Complex morphologies can also arise from differences in growth rate between …
Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration
Intestinal organoids capture essential features of the intestinal epithelium such as crypt
folding, cellular compartmentalization and collective movements. Each of these processes …
folding, cellular compartmentalization and collective movements. Each of these processes …
The wing imaginal disc
BK Tripathi, KD Irvine - Genetics, 2022 - academic.oup.com
The Drosophila wing imaginal disc is a tissue of undifferentiated cells that are precursors of
the wing and most of the notum of the adult fly. The wing disc first forms during …
the wing and most of the notum of the adult fly. The wing disc first forms during …
To form and function: on the role of basement membrane mechanics in tissue development, homeostasis and disease
N Khalilgharibi, Y Mao - Open biology, 2021 - royalsocietypublishing.org
The basement membrane (BM) is a special type of extracellular matrix that lines the basal
side of epithelial and endothelial tissues. Functionally, the BM is important for providing …
side of epithelial and endothelial tissues. Functionally, the BM is important for providing …
[HTML][HTML] Dynamic changes in epithelial cell packing during tissue morphogenesis
Cell packing—the spatial arrangement of cells—determines the shapes of organs. Recently,
investigations of organ development in a variety of model organisms have uncovered …
investigations of organ development in a variety of model organisms have uncovered …
Buckling of an epithelium growing under spherical confinement
A Trushko, I Di Meglio, A Merzouki… - Developmental cell, 2020 - cell.com
Many organs are formed through folding of an epithelium. This change in shape is usually
attributed to tissue heterogeneities, for example, local apical contraction. In contrast …
attributed to tissue heterogeneities, for example, local apical contraction. In contrast …
Mechanical forces directing intestinal form and function
RM Houtekamer, MC van der Net, MM Maurice… - Current Biology, 2022 - cell.com
The vertebrate intestine experiences a range of intrinsically generated and external forces
during both development and adult homeostasis. It is increasingly understood how the …
during both development and adult homeostasis. It is increasingly understood how the …
Cell shape and forces in elastic and structured environments: from single cells to organoids
R Link, K Weißenbruch, M Tanaka… - Advanced Functional …, 2024 - Wiley Online Library
With the advent of mechanobiology, cell shape and forces have emerged as essential
elements of cell behavior and fate, in addition to biochemical factors such as growth factors …
elements of cell behavior and fate, in addition to biochemical factors such as growth factors …