Cancer has been characterized as a genetic disease, associated with mutations that cause
pathological alterations of the cell cycle, adhesion, or invasive motility. Recently, the …

During animal development, cell-fate-specific changes in gene expression can modify the
material properties of a tissue and drive tissue morphogenesis. While mechanistic insights …

Organoids are lumen‐containing multicellular structures that recapitulate key features of the
organs, and are increasingly used in models of disease, drug testing, and regenerative …

Tissue morphogenesis arises from coordinated changes in cell shape driven by actomyosin
contractions. Patterns of gene expression regionalize cell behaviours by controlling …

D'Arcy Thompson was a proponent of applying mathematical and physical principles to
biological systems, an approach that is becoming increasingly common in developmental …

Mammalian embryos change shape dramatically upon implantation. The cellular and
molecular mechanism underlying this transition are largely unknown. Here, we show that …

The assembly of the embryo's primary axis is a fundamental landmark for the establishment
of the vertebrate body plan. Although the morphogenetic movements directing cell …

Epithelial-to-mesenchymal transitions (EMTs) are complex cellular processes where cells
undergo dramatic changes in signaling, transcriptional programming, and cell shape, while …

In vivo, the primary molecular mechanotransductive events mechanically initiating cell
differentiation remain unknown. Here we find the molecular stretching of the highly …

Epithelial− mesenchymal transition (EMT) is an essential process both in physiological and
pathological contexts. Intriguingly, EMT is often associated with tissue invagination during …