Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection

YC Hwang, RM Lu, SC Su, PY Chiang, SH Ko… - Journal of Biomedical …, 2022 - Springer
Abstract The coronavirus disease 2019 (COVID-19) pandemic is an exceptional public
health crisis that demands the timely creation of new therapeutics and viral detection. Owing …

Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies

Y Cao, J Wang, F Jian, T Xiao, W Song, A Yisimayi… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 B. 1.1. 529 (Omicron) variant contains 15 mutations of the
receptor-binding domain (RBD). How Omicron evades RBD-targeted neutralizing antibodies …

Increased resistance of SARS-CoV-2 Omicron variant to neutralization by vaccine-elicited and therapeutic antibodies

T Tada, H Zhou, BM Dcosta, MI Samanovic… - …, 2022 - thelancet.com
Background SARS-CoV-2 vaccines currently authorized for emergency use have been
highly successful in preventing infection and lessening disease severity. The vaccines …

Animal models in SARS-CoV-2 research

H Chu, JFW Chan, KY Yuen - Nature methods, 2022 - nature.com
Animal models in SARS-CoV-2 research | Nature Methods Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

Vaccination-infection interval determines cross-neutralization potency to SARS-CoV-2 Omicron after breakthrough infection by other variants

S Miyamoto, T Arashiro, Y Adachi, S Moriyama… - Med, 2022 - cell.com
Background The immune profile against severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has dramatically diversified due to a complex combination of exposure to …

Structural delineation and computational design of SARS-CoV-2-neutralizing antibodies against Omicron subvariants

S Moriyama, Y Anraku, S Taminishi, Y Adachi… - Nature …, 2023 - nature.com
SARS-CoV-2 Omicron subvariants have evolved to evade receptor-binding site (RBS)
antibodies that exist in diverse individuals as public antibody clones. We rationally selected …

Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients

R Rouet, JY Henry, MD Johansen, M Sobti… - Nature …, 2023 - nature.com
Emerging variants of concern (VOCs) are threatening to limit the effectiveness of SARS-CoV-
2 monoclonal antibodies and vaccines currently used in clinical practice; broadly …

B. 1.1. 529 escapes the majority of SARS-CoV-2 neutralizing antibodies of diverse epitopes

Y Cao, J Wang, F Jian, T Xiao, W Song, A Yisimayi… - BioRxiv, 2021 - biorxiv.org
Abstract The SARS-CoV-2 B. 1.1. 529 variant (Omicron) contains 15 mutations on the
receptor-binding domain (RBD). How Omicron would evade RBD neutralizing antibodies …

Protective neutralizing epitopes in SARS‐CoV‐2

H Liu, IA Wilson - Immunological reviews, 2022 - Wiley Online Library
The COVID‐19 pandemic has caused an unprecedented health crisis and economic burden
worldwide. Its etiological agent SARS‐CoV‐2, a new virus in the coronavirus family, has …