Autism spectrum disorder: classification, diagnosis and therapy

SR Sharma, X Gonda, FI Tarazi - Pharmacology & therapeutics, 2018 - Elsevier
Abstract Autism Spectrum Disorder (ASD) refers to a group of neurodevelopmental disorders
including autism, Asperger's syndrome (AS) and pervasive developmental disorder-not …

Autism, gastrointestinal symptoms and modulation of gut microbiota by nutritional interventions

MV Ristori, A Quagliariello, S Reddel, G Ianiro, S Vicari… - Nutrients, 2019 - mdpi.com
Autism spectrum disorder (ASD) is a complex behavioral syndrome that is characterized by
speech and language disorders, intellectual impairment, learning and motor dysfunctions …

Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice

D Ma, AC Wang, I Parikh, SJ Green, JD Hoffman… - Scientific reports, 2018 - nature.com
Neurovascular integrity, including cerebral blood flow (CBF) and blood-brain barrier (BBB)
function, plays a major role in determining cognitive capability. Recent studies suggest that …

Ketogenic diet: a dietary intervention via gut microbiome modulation for the treatment of neurological and nutritional disorders (a narrative review)

JM Lim, V Letchumanan, LTH Tan, KW Hong, SH Wong… - Nutrients, 2022 - mdpi.com
The ketogenic diet (KD) has been important in treating epilepsy since the 1920s. The
benefits of KD further expanded to other neurological diseases, including Alzheimer's …

The ketogenic diet as a treatment paradigm for diverse neurological disorders

CE Stafstrom, JM Rho - Frontiers in pharmacology, 2012 - frontiersin.org
Dietary and metabolic therapies have been attempted in a wide variety of neurological
diseases, including epilepsy, headache, neurotrauma, Alzheimer disease, Parkinson …

β-Hydroxybutyrate in the brain: one molecule, multiple mechanisms

LB Achanta, CD Rae - Neurochemical research, 2017 - Springer
Abstract β-Hydroxybutyrate (βOHB), a ketone body, is oxidised as a brain fuel. Although its
contribution to energy metabolism in the healthy brain is minimal, it is an interesting …

[HTML][HTML] Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism

BG Allen, SK Bhatia, CM Anderson… - Redox biology, 2014 - Elsevier
Cancer cells, relative to normal cells, demonstrate significant alterations in metabolism that
are proposed to result in increased steady-state levels of mitochondrial-derived reactive …

[HTML][HTML] Mitochondrial dysfunction in autism spectrum disorder: unique abnormalities and targeted treatments

RE Frye - Seminars in pediatric neurology, 2020 - Elsevier
Several lines of evidence implicate mitochondria in the pathophysiology of autism spectrum
disorder (ASD). In this review, we outline some of the evidence supporting this notion, as …

The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies

M Maalouf, JM Rho, MP Mattson - Brain research reviews, 2009 - Elsevier
Both calorie restriction and the ketogenic diet possess broad therapeutic potential in various
clinical settings and in various animal models of neurological disease. Following calorie …

Autism spectrum disorder as a brain-gut-microbiome axis disorder

V Saurman, KG Margolis, RA Luna - Digestive diseases and sciences, 2020 - Springer
While there are numerous medical comorbidities associated with ASD, gastrointestinal (GI)
issues have a significant impact on quality of life for these individuals. Recent findings …