Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …

The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …

Advances in genomics technology have provided the means to probe myriad chromatin
interactions at unprecedented spatial and temporal resolution. This has led to a profound …

Most histones are assembled into nucleosomes behind the replication fork to package newly
synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are …

Chromatin remodelers regulate genes by organizing nucleosomes around promoters, but
their individual contributions are obfuscated by the complex in vivo milieu of factor …

Mechanical deformations of DNA such as bending are ubiquitous and have been implicated
in diverse cellular functions. However, the lack of high-throughput tools to measure the …

R loops form when transcripts hybridize to homologous DNA on chromosomes, yielding a
DNA: RNA hybrid and a displaced DNA single strand. R loops impact the genome of many …

Genome editing with CRISPR-Cas nucleases has been applied successfully to a wide range
of cells and organisms. There is, however, considerable variation in the efficiency of …

Prior studies suggested that SAGA and TFIID are alternative factors that promote RNA
polymerase II transcription, with about 10% of genes in S. cerevisiae dependent on SAGA …

Chromatin-remodelling complexes of the SWI/SNF family function in the formation of
nucleosome-depleted, transcriptionally active promoter regions (NDRs),. In the yeast …