Antisense oligonucleotides are synthetic single stranded strings of nucleic acids that bind to
RNA and thereby alter or reduce expression of the target RNA. They can not only reduce …

Nucleic acid aptamers are short RNA-or DNA-based affinity reagents typically selected from
combinatorial libraries to bind to a specific target such as a protein, a small molecule, whole …

Neurodegenerative diseases are an enormous public health problem, affecting tens of
millions of people worldwide. Nearly all of these diseases are characterized by …

Lowering of prion protein (PrP) expression in the brain is a genetically validated therapeutic
hypothesis in prion disease. We recently showed that antisense oligonucleotide (ASO) …

Prion disease is a fatal, incurable neurodegenerative disease of humans and other
mammals caused by conversion of cellular prion protein (PrP C) into a self-propagating …

In transmissible spongiform encephalopathies, the infectious material consists chiefly of a
protein, the scrapie prion protein PrP Sc, that carries no genetic coding material; however …

The prototypical PrP prion diseases are invariably fatal, and the search for agents to treat
them spans more than 30 years, with limited success. However, in the last few years, the …

Transmissible spongiform encephalopathies (TSEs) are a group of neurodegenerative
disorders that affect humans and other mammals. The etiologic agents common to these …

A misfolded form of the prion protein (PrP) is the primary culprit in mammalian prion
diseases. It has been shown that nucleic acids catalyze the misfolding of cellular PrP into a …

Mice deficient for the cellular prion protein (PrP C) do not develop prion disease;
accordingly, gene-based strategies to diminish PrP C expression are of interest. We …