Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …

Calcium is used in many cellular processes and is maintained within the cell as free calcium
at low concentrations (approximately 100 nM), compared with extracellular (millimolar) …

Endoplasmic reticulum-mitochondria contacts (ERMCs) are restructured in response to
changes in cell state. While this restructuring has been implicated as a cause or …

Mitochondria and lysosomes are critical for cellular homeostasis, and dysfunction of both
organelles has been implicated in numerous diseases. Recently, interorganelle contacts …

Ca 2+ ions are key second messengers in both excitable and non-excitable cells. Owing to
the rather pleiotropic nature of Ca 2+ transporters and other Ca 2+-binding proteins …

Cellular senescence is induced by stresses and results in a stable proliferation arrest
accompanied by a pro-inflammatory secretome. Senescent cells accumulate during aging …

Human coronaviruses (hCoVs) have become a threat to global health and society, as
evident from the SARS outbreak in 2002 caused by SARS-CoV-1 and the most recent …

Recent advances have revealed common pathological changes in neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …

Type 2 diabetic cardiomyopathy features Ca 2+ signaling abnormalities, notably an altered
mitochondrial Ca 2+ handling. We here aimed to study if it might be due to a dysregulation of …

Endoplasmic reticulum (ER) homeostasis requires molecular regulators that tailor
mitochondrial bioenergetics to the needs of protein folding. For instance, calnexin maintains …