The importance of platinum drugs in cancer chemotherapy is underscored by the clinical
success of cisplatin [cis-diamminedichloroplatinum (II)] and its analogues and by clinical …

Platinum chemotherapeutic agents such as cisplatin are currently used in the treatment of
various malignancies such as lung cancer. However, their efficacy is significantly hindered …

Platinum based therapy is one of the most effectively used chemotherapeutic treatments for
cancer. The mechanism of action of platinum compounds is to damage DNA and drive cells …

Our previous studied indicated that eukaryotic translation initiation factor 3a (eIF3a)
increases the sensitive of platinum-based chemotherapy in lung cancer. MiRNAs play an …

Living organisms are constantly threatened by environmental DNA-damaging agents,
including UV and ionizing radiation (IR). Repair of various forms of DNA damage caused by …

The cell cycle has the capacity to safeguard the cell's DNA from damage. Thus, cell cycle
arrest can allow tumor cells to investigate their own DNA repair processes. Cancer cells …

XPC is a 940-residue multidomain protein critical for the sensing of aberrant DNA and
initiation of global genome nucleotide excision repair. The C-terminal portion of XPC …

Purpose: The purpose of this study is to test the hypothesis that eIF3a may regulate the
expression of DNA repair proteins which, in turn, affects response of lung cancer patients to …

Background Renal cancer is insensitive to radiotherapy or most chemotherapies. While the
loss of the XPC gene was correlated with drug resistance in colon cancer, the expression of …

Nucleotide excision repair (NER) pathway plays critical roles in repairing DNA disorders
caused by platinum. To comprehensively understand the association between variants of …