Human induced pluripotent stem cell–derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes
Disease models are essential for understanding cardiovascular disease pathogenesis and
developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology …
developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology …
An overview of injectable polymeric hydrogels for tissue engineering
The desire and need to minimize traditional open surgeries is gearing up as it could reduce
the healthcare expenses and improve the recovery time for the patients. Minimal invasive …
the healthcare expenses and improve the recovery time for the patients. Minimal invasive …
Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts
Y Shiba, T Gomibuchi, T Seto, Y Wada, H Ichimura… - Nature, 2016 - nature.com
Induced pluripotent stem cells (iPSCs) constitute a potential source of autologous patient-
specific cardiomyocytes for cardiac repair, providing a major benefit over other sources of …
specific cardiomyocytes for cardiac repair, providing a major benefit over other sources of …
Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues
IY Shadrin, BW Allen, Y Qian, CP Jackman… - Nature …, 2017 - nature.com
Despite increased use of human induced pluripotent stem cell-derived cardiomyocytes
(hiPSC-CMs) for drug development and disease modeling studies, methods to generate …
(hiPSC-CMs) for drug development and disease modeling studies, methods to generate …
Chemically defined generation of human cardiomyocytes
Existing methods for human induced pluripotent stem cell (hiPSC) cardiac differentiation are
efficient but require complex, undefined medium constituents that hinder further elucidation …
efficient but require complex, undefined medium constituents that hinder further elucidation …
Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions
The protocol described here efficiently directs human pluripotent stem cells (hPSCs) to
functional cardiomyocytes in a completely defined, growth factor–and serum-free system by …
functional cardiomyocytes in a completely defined, growth factor–and serum-free system by …
Dual stem cell therapy synergistically improves cardiac function and vascular regeneration following myocardial infarction
Since both myocardium and vasculature in the heart are excessively damaged following
myocardial infarction (MI), therapeutic strategies for treating MI hearts should concurrently …
myocardial infarction (MI), therapeutic strategies for treating MI hearts should concurrently …
Conversion of human fibroblasts into functional cardiomyocytes by small molecules
Reprogramming somatic fibroblasts into alternative lineages would provide a promising
source of cells for regenerative therapy. However, transdifferentiating human cells into …
source of cells for regenerative therapy. However, transdifferentiating human cells into …
Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells
L Ye, YH Chang, Q Xiong, P Zhang, L Zhang… - Cell stem cell, 2014 - cell.com
Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following
injury, but preclinical studies in large animal models are required to determine optimal cell …
injury, but preclinical studies in large animal models are required to determine optimal cell …
Cyclin D2 overexpression enhances the efficacy of human induced pluripotent stem cell–derived cardiomyocytes for myocardial repair in a swine model of myocardial …
Background: Human induced pluripotent stem cells with normal (wild-type) or upregulated
(overexpressed) levels of CCND2 (cyclin D2) expression were differentiated into …
(overexpressed) levels of CCND2 (cyclin D2) expression were differentiated into …