Controversies surrounding the use of long-acting injectable antipsychotic medications for the treatment of patients with schizophrenia

JM Kane, JP McEvoy, CU Correll, PM Llorca - CNS drugs, 2021 - Springer
Schizophrenia is a serious mental illness that requires continuous and effective long-term
management to reduce symptoms, improve quality of life, and prevent relapse. Oral …

A systematic review and pooled, patient‐level analysis of predictors of mortality in neuroleptic malignant syndrome

D Guinart, F Misawa, JM Rubio… - Acta Psychiatrica …, 2021 - Wiley Online Library
Objective Neuroleptic malignant syndrome (NMS) is a potentially fatal, idiosyncratic reaction
to antipsychotics. Due to low incidence of NMS, research on risk factors of mortality …

Risk factors, incidence, and outcomes of neuroleptic malignant syndrome on long-acting injectable vs oral antipsychotics in a nationwide schizophrenia cohort

D Guinart, H Taipale, JM Rubio… - Schizophrenia …, 2021 - academic.oup.com
Introduction Long-acting injectable antipsychotics (LAIs) are associated with multiple
positive outcomes in psychosis, but it is unclear whether LAIs are associated with worse …

Long-acting antipsychotics in the treatment of schizophrenia: opportunities and challenges

PM Haddad, CU Correll - Expert Opinion on Pharmacotherapy, 2023 - Taylor & Francis
Introduction Maintenance antipsychotic treatment improves multiple outcomes in people with
schizophrenia. These benefits are challenged by medication nonadherence, which is a …

Long-acting injectable antipsychotic treatment in schizophrenia and co-occurring substance use disorders: a systematic review

AS Coles, D Knezevic, TP George, CU Correll… - Frontiers in …, 2021 - frontiersin.org
Objectives: Co-occurring substance use disorders (SUDs) among individuals with
schizophrenia are a prevalent and complex psychiatric comorbidity, which is associated with …

Unravelling cases of clozapine-related Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in patients reported otherwise: a systematic review

R de Filippis, P Soldevila-Matías… - Journal of …, 2021 - journals.sagepub.com
Background: The drug reaction with eosinophilia and systemic symptoms (DRESS)
syndrome is a drug-induced hypersensitivity reaction. Aims: Aim was to review reports of …

Reasons for antipsychotic treatment switch: a systematic retrospective review of prescription records and prescriber notes

D Guinart, K Varma, Y Segal… - The Journal of …, 2022 - psychiatrist.com
Objective: Switching of antipsychotic medications, which are used for many psychiatric
conditions, is common. However, reasons and clinical documentation of such switches have …

Long-acting injectable second-generation antipsychotics vs placebo and their oral formulations in acute schizophrenia: A systematic review and meta-analysis of …

D Wang, J Schneider-Thoma, S Siafis… - Schizophrenia …, 2024 - academic.oup.com
Abstract Background and Hypothesis Long-acting injectable antipsychotic drugs (LAIs) are
mainly used for relapse prevention but could also be advantageous for acutely ill patients …

Identification and treatment of individuals with childhood-onset and early-onset schizophrenia

CU Correll, C Arango, B Fagerlund, S Galderisi… - European …, 2024 - Elsevier
Approximately 8% of patients with schizophrenia are diagnosed before age 18, and 18%
experience their first symptoms before age 18. This narrative review explores the …

Delphi panel to obtain clinical consensus about using long-acting injectable antipsychotics to treat first-episode and early-phase schizophrenia: treatment goals and …

C Arango, A Fagiolini, P Gorwood, JM Kane… - BMC psychiatry, 2023 - Springer
Background Schizophrenia is mostly a chronic disorder whose symptoms include psychosis,
negative symptoms and cognitive dysfunction. Poor adherence is common and related …