BACKGROUND: Many clinical trials have demonstrated the effectiveness of gabapentin and
pregabalin administration in the perioperative period as an adjunct to reduce acute …

The diversity of GABAA receptor (GABAAR) subunits and the numerous configurations
during subunit assembly give rise to a variety of receptors with different functional properties …

Abstract The K+-Cl− cotransporter KCC2 is responsible for maintaining low Cl−
concentration in neurons of the central nervous system (CNS), which is essential for …

Gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter in the mammalian
central nervous system, plays a key role in the regulation of neuronal transmission …

Potentially noxious stimuli are sensed by specialized nerve cells named nociceptors, which
convey nociceptive signals from peripheral tissues to the central nervous system. The spinal …

Abstract Gamma-aminobutyric acid (GABA), a non-protein-producing amino acid
synthesized from the excitatory amino acid glutamate via the enzyme glutamic acid …

Sigma-1 (σ1) receptor antagonists are promising tools for neuropathic pain treatment, but it
is unknown whether σ1 receptor inhibition ameliorates the neuropathic signs induced by …

Abstract γ-Aminobutyric acid type A receptors that contain the δ subunit (δGABA A receptors)
are expressed in multiple types of neurons throughout the central nervous system, where …

There is a critical need for new analgesics acting through new mechanisms of action, which
could increase the efficacy respect to existing therapies and/or reduce their unwanted …

The sigma-1 receptor is a unique ligand-operated chaperone present in key areas for pain
control, in both the peripheral and central nervous system. Sigma-1 receptors interact with a …