The biosynthesis, structures, and functions of O-glycosylation, as a complex
posttranslational event, is reviewed and compared for the various types of O-glycans. Mucin …

The molecular interactions underlying regulation of the immune response take place in a
nanoscale gap between T cells and antigen-presenting cells, termed the immunological …

It has been proposed that the local segregation of kinases and the tyrosine phosphatase
CD45 underpins T cell antigen receptor (TCR) triggering, but how such segregation occurs …

The specialized junction between a T lymphocyte and an antigen-presenting cell, the
immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring …

Abstract B7-1 and B7-2 are generally thought to have comparable structures and affinities
for their receptors, CD28 and CTLA-4, each of which is assumed to be bivalent. We show …

The recognition of foreign antigens by T lymphocytes is essential to most adaptive immune
responses. It is driven by specific T-cell antigen receptors (TCRs) binding to antigenic …

T cells use finger-like protrusions called 'microvilli'to interrogate their targets, but why they do
so is unknown. To form contacts, T cells must overcome the highly charged, barrier-like layer …

How the T cell receptor engages antigen is known, but not how that'triggers' intracellular
signaling. The first direct support for a mechanism based on the spatial reorganization of …

Recognition of antigen by T cells requires the formation of a specialized junction between
the T cell and the antigen-presenting cell. This junction is generated by the recruitment and …

The glycoprotein CD2 is a costimulatory receptor expressed mainly on T and NK cells that
binds to LFA3, a cell surface protein expressed on eg, antigen-presenting cells. CD2 has an …