Cells die by a variety of mechanisms. Terminally differentiated cells such as neurones die in
a variety of disorders, in part, via parthanatos, a process dependent on the activity of poly …

A large body of evidence indicates that mitochondrial dysfunction has a major role in the
pathogenesis of multiple cardiovascular disorders. Over the past 2 decades, extraordinary …

Mitochondria play key roles in activating apoptosis in mammalian cells. Bcl-2 family
members regulate the release of proteins from the space between the mitochondrial inner …

Apoptosis-inducing factor (AIF) is a mitochondrial oxidoreductase that contributes to cell
death programmes and participates in the assembly of the respiratory chain. Importantly, AIF …

Alterations in mitochondrial function, as observed in neurodegenerative diseases, lead to
disrupted energy metabolism and production of damaging reactive oxygen species. Here …

Abstract Poly-ADP-ribose polymerase-1 (PARP-1)'s multiple roles in the cell span from
maintaining life to inducing death. The processes PARP-1 is involved in include, but are not …

Parthanatos is a form of regulated cell death involved in the pathogenesis of many diseases,
particularly neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease …

Apoptosis-inducing factor (AIF) is a flavin adenine dinucleotide-containing, NADH-
dependent oxidoreductase residing in the mitochondrial intermembrane space whose …

It is now clear that apoptosis does not constitute the sole genetically encoded form of cell
death. Rather, cells can spontaneously undertake or exogenously be driven into a cell death …

Poly (ADP-ribose) polymerase-1 (PARP-1) plays a pivotal role in multiple neurologic
diseases by mediating caspase-independent cell death, which has recently been …