Endurance exercise is a widely accessible, low-cost intervention with a variety of benefits to
multiple organ systems. Exercise improves multiple indices of physical performance and …

Epigenetics and epigenomic medicine encompass a new science of brain and behavior that
are already providing unique insights into the mechanisms underlying brain development …

While selective neuronal death has been an influential theme in Huntington's disease (HD),
there is now a preponderance of evidence that significant neuronal dysfunction precedes …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by
a CAG expansion in the gene-encoding Huntingtin (HTT). Transcriptome dysregulation is a …

Spinocerebellar ataxia type 7 (SCA7) is one of several inherited neurodegenerative
disorders caused by a polyglutamine (polyQ) expansion, but it is the only one in which the …

Transcriptional dysregulation in Huntington's disease (HD) is an early event that shapes the
brain transcriptome by both the depletion and ectopic activation of gene products that …

What causes the tissue-specific pathology of diseases resulting from mutations in
housekeeping genes? Specifically, in spinocerebellar ataxia type 7 (SCA7), a …

Huntington's disease (HD) is caused by an aberrant expansion of CAG repeats in the HTT
gene that mainly affects basal ganglia. Although striatal dysfunction has been widely studied …

Abstract Spinocerebellar ataxia type 7 (SCA7) is a rare autosomal dominant
neurodegenerative disorder characterized by progressive neuronal loss in the cerebellum …

Ataxia is the clinical manifestation of a wide range of disorders. In addition to accurate
clinical assessment, MRI plays a major role in the diagnostic workup, allowing us to …