Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

A novel sprayable adhesive is established (ZnMet-PF127) by the combination of a
thermosensitive hydrogel (Pluronic F127, PF127) and a coordination complex of zinc and …

As a key regulator of bone homeostasis, sclerostin has garnered a lot of interest over the last
two decades. Although sclerostin is primarily expressed by osteocytes and is well known for …

Intervertebral disc (IVD) degeneration (IVDD) is the main cause of low back pain with major
social and economic burdens; however, its underlying molecular mechanisms remain poorly …

Osteoarthritis (OA) is an aging-related degenerative joint disease with a poorly defined
mechanism. Here we report that kindlin-2 is highly expressed in articular chondrocytes and …

The progressive destruction of condylar cartilage is a hallmark of the temporomandibular
joint (TMJ) osteoarthritis (OA); however, its mechanism is incompletely understood. Here, we …

Mesenchymal stromal cells (MSCs) are used to treat infectious and immune diseases and
disorders; however, its mechanism (s) remain incompletely defined. Here we find that bone …

Background The key focal adhesion protein β1 integrin plays an essential role in early
skeletal development. However, roles of β1 integrin expression in osteocytes during the …

Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules consisting of
two ligands joined by a linker, enabling them to simultaneously bind with an E3 ligase and a …

Osteoarthritis (OA) is the most common degenerative joint disease affecting the older
populations globally. Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c), a …