Myc genes are key regulators of cell proliferation, and their deregulation contributes to the
genesis of most human tumours. Recently, a wealth of data has shed new light on the …

Complex cellular events commonly depend on the activity of molecular “machines” that
efficiently couple enzymatic and regulatory functions within a multiprotein assembly. An …

The AAA+ superfamily of ATPases, which contain a homologous ATPase module, are found
in all kingdoms of living organisms where they participate in diverse cellular processes …

The AAA+ ATPases are enzymes containing a P-loop NTPase domain, and function as
molecular chaperones, ATPase subunits of proteases, helicases or nucleic-acid-stimulated …

The packaging of the eukaryotic genome in chromatin presents barriers that restrict the
access of enzymes that process DNA,. To overcome these barriers, cells possess a number …

The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for
acetylation of histone H4 and H2A N-terminal tails in yeast. Its catalytic component, Esa1, is …

The Myc oncoprotein forms a binary activating complex with its partner protein, Max, and a
ternary repressive complex that, in addition to Max, contains the zinc finger protein Miz1 …

Differentiation mechanisms and inflammatory functions of neutrophils and macrophages are
usually studied by genetic and biochemical approaches that require costly breeding and …

The c-Myc protein functions as a transcription factor to facilitate oncogenic transformation;
however, the biochemical and genetic pathways leading to transformation remain …

Hedgehog pathway activation is required for expansion of specific neuronal precursor
populations during development and is etiologic in the human cerebellar tumor …