Cells reprogram gene expression in response to environmental changes by mobilizing
transcriptional activators. The activator protein Gcn4 of the yeast Saccharomyces cerevisiae …

Growth and proliferation of microorganisms such as the yeast Saccharomyces cerevisiae
are controlled in part by the availability of nutrients. When proliferating yeast cells exhaust …

We show that phosphorylation of the a subunit of eukaryotic translation initiation factor 2 (elF-
2) by the protein kinase GCN2 mediates translational control of the yeast transcriptional …

Yeast cell growth and cell division are normally coordinated. The mechanism of this
coordination can be examined by attempting to dissociate the two processes. We have …

The proteasome is responsible for removal of ubiquitinated proteins. Although several
aspects of its regulation (eg, assembly, composition, and post-translational modifications) …

The tRNA m1A58 methyltransferase is composed of two subunits encoded by the essential
genes TRM6 and TRM61 (formerly GCD10 and GCD14). The trm6-504 mutation results in a …

GCN4 encodes a transcriptional activator of amino acid biosynthetic genes in yeast that is
regulated at the translational level. The 5′ leader of GCN4 mRNA contains four small open …

The General Amino Acid Control is a conserved response to amino acid starvation involving
activation of protein kinase Gcn2, which phosphorylates eukaryotic initiation factor 2 (eIF2α) …

When subjected to starvation, stress, or viral infections, mammalian cells down-regulate
general protein synthesis by phosphorylating the subunit of eukaryotic translation initiation …

The GCN4 gene encodes a positive regulator of unlinked amino acid biosynthetic genes in
yeast. I present evidence that the GCN4 gene is itself regulated by amino acid availability …