[HTML][HTML] Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

Z Pang, R Raudonis, BR Glick, TJ Lin, Z Cheng - Biotechnology advances, 2019 - Elsevier
Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity
and mortality in cystic fibrosis patients and immunocompromised individuals. Eradication of …

Small molecule anti-biofilm agents developed on the basis of mechanistic understanding of biofilm formation

K Qvortrup, LD Hultqvist, M Nilsson… - Frontiers in …, 2019 - frontiersin.org
Microbial biofilms are the cause of persistent infections associated with various medical
implants and distinct body sites such as the urinary tract, lungs, and wounds. Compared with …

Pyoverdine-Dependent Virulence of Pseudomonas aeruginosa Isolates From Cystic Fibrosis Patients

D Kang, AV Revtovich, Q Chen, KN Shah… - Frontiers in …, 2019 - frontiersin.org
The development of therapies that modulate or prevent pathogen virulence may be a key
strategy for circumventing antimicrobial resistance. Toward that end, we examined the …

Interdependence between iron acquisition and biofilm formation in Pseudomonas aeruginosa

D Kang, NV Kirienko - Journal of microbiology, 2018 - Springer
Bacterial biofilms remain a persistent threat to human healthcare due to their role in the
development of antimicrobial resistance. To combat multi-drug resistant pathogens, it is …

Pseudomonas Quinolone Signal-Induced Outer Membrane Vesicles Enhance Biofilm Dispersion in Pseudomonas aeruginosa

AC Cooke, C Florez, EB Dunshee, AD Lieber, ML Terry… - Msphere, 2020 - Am Soc Microbiol
Bacterial biofilms are major contributors to chronic infections in humans. Because they are
recalcitrant to conventional therapy, they present a particularly difficult treatment challenge …

Age of Antibiotic Resistance in MDR/XDR Clinical Pathogen of Pseudomonas aeruginosa

A Kothari, R Kherdekar, V Mago, M Uniyal, G Mamgain… - Pharmaceuticals, 2023 - mdpi.com
Antibiotic resistance in Pseudomonas aeruginosa remains one of the most challenging
phenomena of everyday medical science. The universal spread of high-risk clones of …

Novel insights on pyoverdine: from biosynthesis to biotechnological application

F Dell'Anno, GA Vitale, C Buonocore, L Vitale… - International Journal of …, 2022 - mdpi.com
Pyoverdines (PVDs) are a class of siderophores produced mostly by members of the genus
Pseudomonas. Their primary function is to accumulate, mobilize, and transport iron …

Cheminformatics Bioprospection of Sunflower Seeds' Oils against Quorum Sensing System of Pseudomonas aeruginosa

NW S'thebe, JO Aribisala, S Sabiu - Antibiotics, 2023 - mdpi.com
Clinically significant pathogens such as Pseudomonas aeruginosa evade the effects of
antibiotics using quorum sensing (QS) systems, making antimicrobial resistance (AMR) a …

A small-molecule inhibitor of the anthranilyl-CoA synthetase PqsA for the treatment of multidrug-resistant Pseudomonas aeruginosa

J Chen, Y Lu, F Ye, H Zhang, Y Zhou, J Li… - Microbiology …, 2022 - Am Soc Microbiol
One of the challenges associated with the treatment of Pseudomonas aeruginosa infections
is the high prevalence of multidrug resistance (MDR). Since conventional antibiotics are …

Structural analysis of novel drug targets for mitigation of Pseudomonas aeruginosa biofilms

M Ghosh, S Raghav, P Ghosh, S Maity… - FEMS Microbiology …, 2023 - academic.oup.com
Pseudomonas aeruginosa is an opportunistic human pathogen responsible for acute and
chronic, hard to treat infections. Persistence of P. aeruginosa is due to its ability to develop …